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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
43.03
Human Site:
S449
Identified Species:
67.62
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S449
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S457
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S443
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Dog
Lupus familis
XP_534241
2041
231068
S867
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S437
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Rat
Rattus norvegicus
P41516
1526
173202
S426
I
Q
L
N
K
K
C
S
A
V
K
H
N
R
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S752
T
Q
L
N
K
K
C
S
S
V
K
Y
S
K
I
Chicken
Gallus gallus
O42131
1627
183228
S454
T
Q
L
N
K
K
C
S
S
V
K
H
S
K
I
Frog
Xenopus laevis
NP_001082502
1579
178601
S426
T
Q
L
N
K
K
C
S
A
V
K
H
T
K
I
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S448
T
Q
L
N
K
K
C
S
S
V
K
H
S
K
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Q366
K
E
N
M
T
L
Q
Q
K
G
F
G
S
K
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S439
K
F
S
K
A
A
S
S
V
G
I
T
D
A
V
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K367
N
Q
I
I
Q
T
V
K
K
K
N
K
A
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S392
L
R
Q
S
S
F
G
S
K
C
E
L
S
E
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
N347
V
K
S
F
Q
I
K
N
N
M
F
I
F
I
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
100
66.6
N.A.
100
93.3
80
93.3
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
100
100
100
100
N.A.
20
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
0
0
14
0
0
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
67
0
0
7
0
0
0
0
7
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% D
% Glu:
0
7
0
0
0
0
0
0
0
0
7
0
0
7
0
% E
% Phe:
0
7
0
7
0
7
0
0
0
0
14
0
7
0
0
% F
% Gly:
0
0
0
0
0
0
7
0
0
14
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
27
0
0
0
% H
% Ile:
7
0
7
7
0
7
0
0
0
0
7
7
0
7
74
% I
% Lys:
14
7
0
7
67
67
7
7
20
7
67
7
0
67
0
% K
% Leu:
7
0
67
0
0
7
0
0
0
0
0
7
0
0
0
% L
% Met:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
7
0
7
67
0
0
0
7
7
0
7
0
7
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
74
7
0
14
0
7
7
0
0
0
0
0
0
0
% Q
% Arg:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
0
14
7
7
0
7
80
54
0
0
0
67
0
0
% S
% Thr:
60
0
0
0
7
7
0
0
0
0
0
7
7
0
0
% T
% Val:
7
0
0
0
0
0
7
0
7
67
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
40
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _